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Plasma chemical deposition of thin polymer layers based on 2-ethyl-2-oxazoline and their diagnostics
Podzemná, Erika ; Horák, Jakub (referee) ; Mazánková, Věra (advisor)
Medical devices are often subject to the colonisation of bacteria, making it a prerequisite for infection in the patient's body. To prevent biofilm, the medical device can be covered with a thin layer of polymeric substance that has the ability to prevent biological fouling. In this work, was selected 2-ethyl-2-oxazoline as a precursor for the formation of thin polymer layers. In general, the oxazoline group is known for its antibacterial and biocompatible properties, which is the reason for choosing this substance. The main objective of this thesis was the deposition of thin polymer films, which are based on 2-ethyl-2-oxazoline, in surface dielectric barrier discharge under atmospheric pressure. The principle of thin layer formation on a teflon substrate is plasma polymerization. The preparation of the layers was followed by their characterization by several methods. Their physical and chemical properties were studied using SEM, FTIR, and by measuring the contact angles of the surface of the layers. Furthermore, the processes that take place in plasma, when there is an interaction of electrons and ions with the monomer molecule, were investigated. Ion mobility spectrometry and the crossed-beam ionization method were used for this measurement. The layers were also tested for their antibacterial and cytocompatible properties.
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